影片故事设定在一个融合东西方文化（旧金山+东京）的虚构大都市旧京山（SanFransokyo）中，一位精通机器人技术的小神童滨田广（Hiro Hamada）发现，这座充斥高新技术的城市正遭遇着一场犯罪危机，为了拆穿阴谋拯救家园，他将携伙伴机器人Baymax，与一伙生拉硬凑的菜鸟团队组成“六大英雄”联盟，共同作战抗击罪恶。



Protagonist Hiro Hamada is a 14-year-old robotics genius who lives in the futuristic (fictional) city of San Fransokyo and spends his time participating in illegal robot fights; to amend which, his older brother Tadashi takes him to the robotics center at his university, where Hiro meets Tadashi's friends: GoGo, Wasabi, Honey Lemon, and Fred, as well the healthcare robot Baymax that Tadashi created. To enroll in the school, Hiro presents microbots: swarms of tiny robots that can link together in any arrangement imaginable — to Professor Callaghan, the head of the school's robotics program. When a fire breaks out at the university, Tadashi rushes in to rescue Callaghan, but both are killed, and Hiro secludes himself. One day, Hiro accidentally activates Baymax, who follows one of his microbots to an abandoned warehouse. There, the two discover that someone has been mass-producing Hiro's microbots, and they are attacked by a masked man in control of them. To catch the man, Hiro equips Baymax with armor and a chip containing various Karate moves. After the masked man attacks Hiro, Baymax, GoGo, Wasabi, Honey, and Fred, the six form a superhero team, who discover a former laboratory of Krei Tech, a prestigious robotics company experimenting with teleportation technology until the disappearance of a test pilot, and identify the masked man as Professor Callaghan, who stole Hiro's bots to escape the fire. Realizing that Tadashi died in vain, Hiro removes Baymax's healthcare chip and orders him to kill Callaghan. Baymax almost does so, but Honey re-installs the healthcare chip to stop him. To console Hiro,

Baymax plays several humorous videos of Tadashi running tests during Baymax's development. ...